Neurexins cluster Ca 2+ channels within the presynaptic active zone
نویسندگان
چکیده
منابع مشابه
The Presynaptic Active Zone
Neurotransmitters are released by synaptic vesicle exocytosis at the active zone of a presynaptic nerve terminal. In this review, I discuss the molecular composition and function of the active zone. Active zones are composed of an evolutionarily conserved protein complex containing as core constituents RIM, Munc13, RIM-BP, α-liprin, and ELKS proteins. This complex docks and primes synaptic vesi...
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The amyloid precursor protein (APP) was discovered in the 1980s as the precursor protein of the amyloid A4 peptide. The amyloid A4 peptide, also known as A-beta (Aβ), is the main constituent of senile plaques implicated in Alzheimer's disease (AD). In association with the amyloid deposits, increasing impairments in learning and memory as well as the degeneration of neurons especially in the hip...
متن کاملThe active-zone protein Munc13 controls the use-dependence of presynaptic voltage-gated calcium channels
Presynaptic calcium channel function is critical for converting electrical information into chemical communication but the molecules in the active zone that sculpt this function are poorly understood. We show that Munc13, an active-zone protein essential for exocytosis, also controls presynaptic voltage-gated calcium channel (VGCC) function dictating their behavior during various forms of activ...
متن کاملThe Active-zone Protein Munc13 Controls the Use-dependence of Presynaptic Voltage-gated Calcium 1 Channels 2
Presynaptic calcium channel function is critical for converting electrical information into chemical 8 communication but the molecules in the active zone that sculpt this function are poorly understood. 9 We show that Munc13, an active-zone protein essential for exocytosis, also controls presynaptic 10 voltage-gated calcium channel function dictating their behavior during various forms of activ...
متن کاملActive zone localization of presynaptic calcium channels encoded by the cacophony locus of Drosophila.
Presynaptic calcium channels play a central role in chemical synaptic transmission by providing the calcium trigger for evoked neurotransmitter release. These voltage-gated calcium channels are composed of a primary structural subunit, alpha1, as well as auxiliary beta and alpha2delta subunits. Our previous genetic, molecular, and functional analysis has shown that the cacophony (cac) gene enco...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2020
ISSN: 0261-4189,1460-2075
DOI: 10.15252/embj.2019103208